Metal cations are indispensable components of the cellular machinery and are involved in
numerous essential tasks ranging from nucleic acid and protein structure stabilization to …

Voltage-gated sodium channels are responsible for the rising phase of the action potential in
the membranes of neurons and most electrically excitable cells. Exploration of the molecular …

INTRODUCTION Voltage-gated sodium (Nav) channels are responsible for the generation
and propagation of action potentials in excitable cells. They undergo voltage-dependent …

Voltage-gated sodium channel Na v 1.5 generates cardiac action potentials and initiates the
heartbeat. Here, we report structures of Na V 1.5 at 3.2–3.5 Å resolution. Na V 1.5 is …

Selective permeation of sodium ions through voltage-dependent sodium channels is
fundamental to the generation of action potentials in excitable cells such as neurons. These …

Complex multicellular organisms require rapid and accurate transmission of information
among cells and tissues and tight coordination of distant functions. Electrical signals and …

The pore-forming subunits of canonical voltage-gated sodium and calcium channels are
encoded by four repeated domains of six-transmembrane (6TM) segments. We expressed …

Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …

Objective: Most mutations in SCN1A-related epilepsies are novel and when an infant
presents with febrile seizures (FS) it is uncertain if they will have simple FS, FS+, or develop …

Voltage-gated sodium (Nav) channels are essential for the rapid upstroke of action
potentials and the propagation of electrical signals in nerves and muscles. Defects of Nav …