Pressurised intraperitoneal aerosol chemotherapy: rationale, evidence, and potential indications
M Alyami, M Hübner, F Grass, N Bakrin… - The Lancet …, 2019 - thelancet.com
Pressurised intraperitoneal aerosol chemotherapy (PIPAC) was introduced as a new
treatment for patients with peritoneal metastases in November, 2011. Reports of its …
treatment for patients with peritoneal metastases in November, 2011. Reports of its …
[HTML][HTML] Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?
Colorectal cancer commonly metastasizes. The liver is the most frequent site of metastases
and dominates the length of survival for this disease. As surgical and systemic therapies …
and dominates the length of survival for this disease. As surgical and systemic therapies …
Medium-throughput drug screening of patient-derived organoids from colorectal peritoneal metastases to direct personalized therapy
Purpose: Patients with colorectal cancer with peritoneal metastases (CRPMs) have limited
treatment options and the lowest colorectal cancer survival rates. We aimed to determine …
treatment options and the lowest colorectal cancer survival rates. We aimed to determine …
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) for unresectable peritoneal metastasis from gastric cancer
M Alyami, PE Bonnot, F Mercier, N Laplace… - European journal of …, 2021 - Elsevier
Background PIPAC is a recent approach with promising results for patients with peritoneal
metastasis (PM). We aimed to evaluate survival and postoperative outcome of patients with …
metastasis (PM). We aimed to evaluate survival and postoperative outcome of patients with …
Treatment of peritoneal metastasis with pressurized intraperitoneal aerosol chemotherapy: results from the prospective PIPAC-OPC2 study
M Graversen, S Detlefsen, AP Ainsworth… - Annals of Surgical …, 2023 - Springer
Abstract Background Pressurized Intraperitoneal Aerosol chemotherapy (PIPAC) is a local
treatment for peritoneal metastasis (PM). Prospective data are scarce and evaluation of …
treatment for peritoneal metastasis (PM). Prospective data are scarce and evaluation of …
The effect of electrostatic high pressure nebulization on the stability, activity and ex vivo distribution of ionic self-assembled nanomedicines
H Braet, V Andretto, R Mariën, B Yücesan… - Acta Biomaterialia, 2023 - Elsevier
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is applied to treat unresectable
peritoneal metastasis (PM), an advanced, end-stage disease with a poor prognosis …
peritoneal metastasis (PM), an advanced, end-stage disease with a poor prognosis …
[HTML][HTML] Overcoming drug resistance by taking advantage of physical principles: pressurized intraperitoneal aerosol chemotherapy (PIPAC)
G Nadiradze, P Horvath, Y Sautkin, R Archid… - Cancers, 2019 - mdpi.com
Theoretical considerations as well as comprehensive preclinical and clinical data suggest
that optimizing physical parameters of intraperitoneal drug delivery might help to circumvent …
that optimizing physical parameters of intraperitoneal drug delivery might help to circumvent …
Pressurized intraperitoneal aerosol chemotherapy (oxaliplatin) for unresectable colorectal peritoneal metastases: a multicenter, single-arm, phase II trial (CRC-PIPAC)
KP Rovers, ECE Wassenaar, RJ Lurvink… - Annals of Surgical …, 2021 - Springer
Background Despite its increasing use, pressurized intraperitoneal aerosol chemotherapy
with oxaliplatin (PIPAC-OX) has never been prospectively investigated as a palliative …
with oxaliplatin (PIPAC-OX) has never been prospectively investigated as a palliative …
Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions
H Braet, PP Fransen, Y Chen, S Van Herck… - Journal of Controlled …, 2023 - Elsevier
Postoperative peritoneal adhesions occur in the majority of patients undergoing intra-
abdominal surgery and are one of the leading causes of hospital re-admission. There is an …
abdominal surgery and are one of the leading causes of hospital re-admission. There is an …
Feasibility, safety, and efficacy of pressurized intraperitoneal aerosol chemotherapy (PIPAC) for peritoneal metastasis: a registry study
F Kurtz, F Struller, P Horvath, W Solass… - Gastroenterology …, 2018 - Wiley Online Library
Introduction. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel drug
delivery system with superior pharmacological properties for treating peritoneal metastasis …
delivery system with superior pharmacological properties for treating peritoneal metastasis …