DNA methylation in systemic lupus erythematosus

CM Hedrich, K Mäbert, T Rauen, GC Tsokos - Epigenomics, 2017 - Taylor & Francis
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by
aberrant immune responses directed against cells and tissues, resulting in inflammation and …

Drivers of the immunopathogenesis in systemic lupus erythematosus

T Rose, T Dörner - Best practice & research Clinical rheumatology, 2017 - Elsevier
This review summarises a number of current insights into the pathogenesis of SLE. On the
basis of the interaction of environmental factors within a predisposed host, a chronic …

Type I interferon gene response is increased in early and established rheumatoid arthritis and correlates with autoantibody production

JE Castañeda-Delgado, Y Bastián-Hernandez… - Frontiers in …, 2017 - frontiersin.org
Background Rheumatoid arthritis (RA) is an inflammatory debilitating disease that affects the
joints in the early and productive phases of an individual's life. Several cytokines have been …

Personalized inherent randomness of the immune system is manifested by an individualized response to immune triggers and immunomodulatory therapies: a novel …

M El-Haj, D Kanovitch, Y Ilan - Immunologic Research, 2019 - Springer
The considerable variability of responses amongst subjects to disease triggers and
immunotherapies is a major obstacle to designing better immune-based therapies …

SIGLEC1 is a biomarker of disease activity and indicates extraglandular manifestation in primary Sjögren's syndrome

T Rose, F Szelinski, A Lisney, K Reiter, SJ Fleischer… - RMD open, 2016 - rmdopen.bmj.com
Objectives To evaluate the interferon (IFN) biomarkers sialic acid binding Ig like lectin 1
(SIGLEC1, CD169) and IFN-γ-inducible protein-10 (IP-10) in patients with primary Sjögren's …

New perspectives in rheumatology: biomarkers as entry criteria for clinical trials of new therapies for systemic lupus erythematosus: the example of antinuclear …

DS Pisetsky, BH Rovin, PE Lipsky - Arthritis & Rheumatology, 2017 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease that
represents a great challenge for current therapy as well as new drug development (1, 2) …

Label-free piezoelectric biosensor for prognosis and diagnosis of Systemic Lupus Erythematosus

NM do Nascimento, A Juste-Dolz, E Grau-García… - Biosensors and …, 2017 - Elsevier
An autoantigen piezoelectric sensor to quantify specific circulating autoantibodies in human
serum is developed. The sensor consisted on a quartz crystal microbalance with dissipation …

Osmium-labeled microspheres for bead-based assays in mass cytometry

L Budzinski, AR Schulz, S Baumgart… - The Journal of …, 2019 - journals.aai.org
Polystyrene beads are broadly applied in flow cytometry. Implementing bead-based assays
in mass cytometry is desired but hampered by the lack of an elemental label required for …

Three clinical clusters identified through hierarchical cluster analysis using initial laboratory findings in Korean patients with systemic lupus erythematosus

JY Jung, HY Lee, E Lee, HA Kim, D Yoon… - Journal of Clinical …, 2022 - mdpi.com
Systemic lupus erythematosus (SLE) is a heterogeneous disorder with diverse clinical
manifestations. This study classified patients by combining laboratory values at SLE …

RNA-seq analysis of gene expression, viral pathogen, and B-cell/T-cell receptor signatures in complex chronic disease

J Bouquet, JL Gardy, S Brown, J Pfeil… - Clinical Infectious …, 2017 - academic.oup.com
Background. Chronic fatigue syndrome (CFS) remains poorly understood. Although
infections are speculated to trigger the syndrome, a specific infectious agent and underlying …