Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …

Pain is a prevalent complex medical problem, characterized by physically debilitating and
mentally destabilizing conditions. Current pain therapeutics mainly include non-steroidal …

BACKGROUND: Increasing attention has been attracted to the development of bifunctional
compounds to minimize the side effects of opioid analgesics. Pharmacological studies have …

Background and Purpose The voltage‐gated sodium channel NaV1. 7 is considered a
therapeutic target for pain treatment based on human genetic evidence. GpTx‐1 and its …

The development of multitarget opioid drugs has emerged as an attractive therapeutic
strategy to eliminate opioid-related side effects. Our previous study developed a series of …

Evidence accumulated over the past decades has revealed that red blood cells and
hemoglobin (Hb) in the blood play important roles in modulating moods and emotions. The …

Cannabinoid receptors (CBRs) are part of the endocannabinoid system, which is involved in
various physiological processes such as nociception, inflammation, appetite, stress, and …

Pharmacological investigations have substantiated the potential of bifunctional
opioid/cannabinoid agonists in delivering potent analgesia while minimizing adverse …

Abstract Mouse VD-hemopressin (α)(VD-Hpα) is an undecapeptide that selectively activates
CB 1 cannabinoid receptor in in vitro functional tests, and exerts CB 1-mediated central …

Hemopressin and related peptides have shown to function as the endogenous ligands or
the regulator of cannabinoid receptors. Moreover, hemopressin and its truncated peptides …