Prostate specific antigen (PSA) remains the most used biomarker in the management of
early prostate cancer (PCa), in spite of the problems related to false positive results and …

Background Inherited mutations in DNA-repair genes such as BRCA2 are associated with
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …

Epidemiological data highlight prostate cancer as a significant global health issue, with high
incidence and substantial impact on patients' quality of life. The prevalence of this disease is …

Objective Evidence shows that gene mutation is a significant proportion of genetic factors
associated with prostate cancer. The DNA damage response (DDR) is a signal cascade …

Importance Germline gene panel testing is recommended for men with advanced prostate
cancer (PCa) or a family history of cancer. While evidence is limited for some genes …

Prostate cancer (PCa) risk-associated SNPs are enriched in noncoding cis-regulatory
elements (rCREs), yet their modi operandi and clinical impact remain elusive. Here, we …

Prostate cancer (PCa) shows a broad spectrum of biological and clinical behavior, which
represents the epiphenomenon of an extreme genetic heterogeneity. Recent genomic …

Prostate cancer aggressiveness and metastatic potential are influenced by gene expression
and genomic aberrations, features that can be influenced by the 3D structure of …

Hereditary factors have a strong influence on prostate cancer (PC) risk and poorer
outcomes, thus stratification by genetic factors addresses a critical need for targeted PC …

Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …