Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

P Shi, S Xie, J Yang, Y Zhang, S Han, S Su… - Frontiers in …, 2022 - frontiersin.org
Bee venom (BV), a type of defensive venom, has been confirmed to have favorable
activities, such as anti-tumor, neuroprotective, anti-inflammatory, analgesic, anti-infectivity …

Powering amyloid beta degrading enzymes: a possible therapy for Alzheimer's disease

NL Sikanyika, HC Parkington, AI Smith… - Neurochemical …, 2019 - Springer
The accumulation of amyloid beta (Aβ) in the brain is believed to play a central role in the
development and progression of Alzheimer's disease. Revisions to the amyloid cascade …

Animal protein toxins: origins and therapeutic applications

N Chen, S Xu, Y Zhang, F Wang - Biophysics reports, 2018 - Springer
Venomous animals on the earth have been found to be valuable resources for the
development of therapeutics. Enzymatic and non-enzymatic proteins and peptides are the …

New rice-derived short peptide potently alleviated hyperuricemia induced by potassium oxonate in rats

N Liu, Y Wang, M Yang, W Bian, L Zeng… - Journal of Agricultural …, 2018 - ACS Publications
Gout that caused by hyperuricemia affects human health seriously and more efficient drugs
are urgently required clinically. In this study, a novel peptide named RDP1 (AAAAGAKAR …

Animal-derived medicinal products in Russia: Current nomenclature and specific aspects of quality control

IA Prokopov, EL Kovaleva, ED Minaeva… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Animal-derived medicinal products (ADMP) had been
extensively used in Russia and became a part of officinal medicine in 1778. Aim of the study …

The role of toxins in the pursuit for novel analgesics

Y Maatuf, M Geron, A Priel - Toxins, 2019 - mdpi.com
Chronic pain is a major medical issue which reduces the quality of life of millions and inflicts
a significant burden on health authorities worldwide. Currently, management of chronic pain …

Recent progress in non-opioid analgesic peptides

MJP de Vega, A Ferrer-Montiel… - Archives of biochemistry …, 2018 - Elsevier
Pain is a prevalent complex medical problem, characterized by physically debilitating and
mentally destabilizing conditions. Current pain therapeutics mainly include non-steroidal …

[HTML][HTML] Revisiting the potential of South American rattlesnake Crotalus durissus terrificus toxins as therapeutic, theranostic and/or biotechnological agents

MAF Hayashi, JD Campeiro, CM Yonamine - Toxicon, 2022 - Elsevier
The potential biotechnological and biomedical applications of the animal venom
components are widely recognized. Indeed, many components have been used either as …

CCR1 enhances SUMOylation of DGCR8 by up-regulating ERK phosphorylation to promote spinal nerve ligation-induced neuropathic pain

C Shi, J Jin, H Xu, J Ma, T Li, Y Xie, Z Li - Gene Therapy, 2022 - nature.com
Neuropathic pain is a somatosensory nervous system dysfunction that remains a threatening
health problem globally. Recent studies have highlighted the involvement of CC motif …

Antinociceptive peptides from venomous arthropods

JAI Muller, LY Chan, MC Toffoli-Kadri, MR Mortari… - Toxin …, 2023 - Taylor & Francis
Many analgesic peptides have been isolated from arthropod species such as spiders and
scorpions and their three-dimensional structures, which are typically stabilized by several …