This article shows that T cell activation-induced expression of the cytokines IL-2 and-4 is
determined by an oxidative signal originating from mitochondrial respiratory complex I. We …

The role of histamine H 4 receptor (H 4 R) was investigated in a T-helper type 2 (Th2)-cell-
mediated mouse skin inflammation model that mimics several of the features of atopic …

Recently the Th1/Th2 concept has been revised and Th17 cells have been implicated in
allergy. Despite clear correlative evidence, the cellular and molecular basis for the …

Background Atopic dermatitis (AD) is a chronic inflammatory skin disease. The pathogenesis
of AD involves skin barrier defects and dysregulation of innate and adaptive immunity. Some …

Atopic dermatitis is a common inflammatory skin disorder of variable severity characterized
by eczematous skin lesions associated with itching. This disease has an intricate …

Abstract Ethnopharmacological relevance Fritillariae thunbergii Bulbus (FT), knowns as
“Jeolpaemo (浙貝母)” in Korean traditional medicine, is a perennial plant belonging to the …

Mice lacking heterogenous nuclear ribonuclear protein D (Hnrnpd), also known as Auf1, a
regulator of inflammatory cytokine mRNA stability, develop chronic dermatitis with age that is …

The field of histamine research has progressed far from a century ago when the first
biological functions of histamine were identified. It is now known that histamine function is …

Scurfy (Sf) mice bear a mutation in the Foxp3 transcription factor, lack regulatory T cells
(Treg), develop multiorgan inflammation, and die prematurely. The major target organs …

Ethnopharmacological relevance Phyllostachys nigra (PN) is an herbal medicine that
originates from the inner bark of Phyllostachys nigra Munro var. henosis Stapf or …