Protein misfolding and aggregation: Mechanism, factors and detection

SK Chaturvedi, MK Siddiqi, P Alam, RH Khan - Process Biochemistry, 2016 - Elsevier
Amyloidogenic diseases are characterised by the formation of amyloid aggregates inside or
outside the cell. Amyloid-associated human diseases include Alzheimer's disease …

Inhibitory effect of phloretin on α-glucosidase: Kinetics, interaction mechanism and molecular docking

L Han, C Fang, R Zhu, Q Peng, D Li, M Wang - International Journal of …, 2017 - Elsevier
As the aglycone of phloridzin, phloretin belongs to dihydrochalcone with antioxidant, anti-
inflammatory and antimicrobial activities. In this study, multispectroscopic techniques and …

Effects of (−)-epigallocatechin-3-gallate on the functional and structural properties of soybean protein isolate

Y You, L Yang, H Chen, L Xiong… - Journal of Agricultural and …, 2021 - ACS Publications
In the present study, soy protein isolate (SPI) was noncovalently modified by (−)-
epigallocatechin-3-gallate (EGCG), and its foaming, emulsifying, and antioxidant properties …

Vitamin k3 inhibits protein aggregation: implication in the treatment of amyloid diseases

P Alam, SK Chaturvedi, MK Siddiqi, RK Rajpoot… - Scientific reports, 2016 - nature.com
Protein misfolding and aggregation have been associated with several human diseases
such as Alzheimer's, Parkinson's and familial amyloid polyneuropathy etc. In this study, anti …

Spectrofluorimetric and molecular docking studies on the interaction of cyanidin-3-O-glucoside with whey protein, β-lactoglobulin

J Cheng, JH Liu, G Prasanna, P Jing - International journal of biological …, 2017 - Elsevier
The interaction of β-Lactoglobulin (β-Lg) with cyanidin-3-O-glucoside (C3G) was
characterized using fluorescence, circular dichroism spectroscopy, and docking studies …

Investigation of inhibitory potential of quercetin to the pyruvate dehydrogenase kinase 3: Towards implications in anticancer therapy

R Dahiya, T Mohammad, S Roy, S Anwar… - International journal of …, 2019 - Elsevier
Abstract Pyruvate dehydrogenase kinase 3 (PDK3) is a mitochondrial protein, has recently
been considered as a potential pharmacological target for varying types of cancer. Here, we …

Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity

P Alam, AZ Beg, MK Siddiqi, SK Chaturvedi… - Archives of biochemistry …, 2017 - Elsevier
Protein aggregation into oligomers and fibrils are associated with many human
pathophysiologies. Compounds that modulate protein aggregation and interact with …

Changes in structural and functional properties of whey protein cross-linked by polyphenol oxidase

R Yang, H Shao, Y Yan, Y Wu, X Meng, A Yang… - Food Research …, 2023 - Elsevier
The natural whey protein is unstable, to achieve more efficient utilization, the functional
properties of whey protein were modified by changing its structure, and enzymatic cross …

Comparative interaction study of soy protein isolate and three flavonoids (Chrysin, Apigenin and Luteolin) and their potential as natural preservatives

M Li, J Kong, Y Chen, Y Li, H Xuan, M Liu, Q Zhang… - Food Chemistry, 2023 - Elsevier
In this work, the potential of soy protein isolate (SPI)-luteolin (Lut)/apigenin (Ap)/chrysin
(Chr) complexes as natural preservatives for food and cosmetics was evaluated by …

Understanding the binding between Rosmarinic acid and serum albumin: In vitro and in silico insight

A Shamsi, A Ahmed, MS Khan, M Al Shahwan… - Journal of Molecular …, 2020 - Elsevier
Rosmarinic acid (RA) is a natural product that is increasingly being used in food industries
and cosmetic industries. Drug pharmacokinetics is affected upon binding with protein, thus …