Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

The BRAF inhibitors vemurafenib, dabrafenib and encorafenib are used in the treatment of
patients with BRAF-mutant melanoma. They selectively target BRAF kinase and thus …

New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a
broad range of biological processes, including the pathogenesis of many complex human …

First administered to a human subject as a tuberculosis (TB) vaccine on July 18, 1921,
Bacillus Calmette-Guérin (BCG) has a long history of use for the prevention of TB and later …

Simple Summary Malignant melanoma is more dangerous than most other skin cancers due
to its ability to spread early and aggressively. Until the development of new therapeutic …

Purpose To investigate the ability of 18 F-FDG PET/CT to assess the response of patients
with metastatic melanoma to immunotherapy. Methods A comprehensive search of the …

Cutaneous melanoma (CM) encompasses a group of pigmented tumors that arise from skin
melanocytes. Melanocytes are neural crest-derived cells that commonly migrate to the skin …

As the incidence of cutaneous malignancies continues to rise and their treatment with
immunotherapy expands, dermatologists and their patients are more likely to encounter …

Importance Although tumor-infiltrating lymphocytes (TILs) are an important histopathologic
characteristic reflecting host immune response in patients with melanoma, their prognostic …

Management of regional lymph nodes in patients with melanoma has evolved significantly in
recent years. The value of nodal intervention, long utilized for its perceived therapeutic …