Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

Neuroinflammation is central to the common pathology of several acute and chronic brain
diseases. This review examines the consequences of excessive and prolonged …

Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

Over the past two decades it became evident that the immune system plays a central role in
modulating learning, memory and neural plasticity. Under normal quiescent conditions …

Astrocyte reactivity is a hallmark of neuroinflammation that arises with Alzheimer's disease
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …

A link between Alzheimer's disease (AD) and metabolic disorders has been established,
with patients with type 2 diabetes at increased risk of developing AD and vice versa. The …

Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the
elderly. The increase of lifeexpectancy is transforming AD into a major health-care problem …

Astrocytes play a role in healthy cognitive function and Alzheimer's disease (AD). The
transcriptional factor nuclear factor-κB (NF-κB) drives astrocyte diversity, but the …

Purpose. NSAIDs constitute an important class of drugs with therapeutic applications that
have spanned several centuries. Treatment of inflammatory conditions such as rheumatoid …