Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …

DNA damage response (DDR) pathway prevents high level endogenous and environmental
DNA damage being replicated and passed on to the next generation of cells via an …

Radiotherapy is used in the treatment of approximately 50% of all malignancies including
gastrointestinal cancers. Radiation can be given prior to surgery (neoadjuvant radiotherapy) …

The cell cycle checkpoint proteins ataxia-telangiectasia-mutated-and-Rad3-related kinase
(ATR) and its major downstream effector checkpoint kinase 1 (CHK1) prevent the entry of …

The DNA damage response (DDR) is now known to play an important role in both cancer
development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia …

The DNA damage response (DDR) machinery is responsible for detecting DNA damage,
pausing the cell cycle and initiating DNA repair. Ataxia telangiectasia and Rad3-related …

Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …

Chemoresistance, radioresistance, and the challenge of achieving complete resection are
major driving forces in the search for more robust and targeted anticancer therapies …

Simple Summary As hypoxia-inducible factor 1 (HIF-1) is recognized as a target for cancer
therapy, extensive efforts have been devoted to developing its inhibitors. We provide an …

Malignant pheochromocytoma–paraganglioma: pathogenesis, TNM... : Current Opinion in
Endocrinology, Diabetes and Obesity Malignant pheochromocytoma–paraganglioma …