[HTML][HTML] Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

[HTML][HTML] History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

[HTML][HTML] Mechanisms and treatment of late-life depression

GS Alexopoulos - Translational psychiatry, 2019 - nature.com
Depression predisposes to medical illnesses and advances biological aging indicated by
shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical …

[HTML][HTML] Depression—an underrecognized target for prevention of dementia in Alzheimer's disease

FS Dafsari, F Jessen - Translational psychiatry, 2020 - nature.com
It is broadly acknowledged that the onset of dementia in Alzheimer's disease (AD) may be
modifiable by the management of risk factors. While several recent guidelines and …

Extracellular vesicles round off communication in the nervous system

V Budnik, C Ruiz-Cañada, F Wendler - Nature Reviews Neuroscience, 2016 - nature.com
Functional neural competence and integrity require interactive exchanges among sensory
and motor neurons, interneurons and glial cells. Recent studies have attributed some of the …

[HTML][HTML] Alzheimer's disease and gut microbiota

X Hu, T Wang, F Jin - Science China Life Sciences, 2016 - Springer
Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates
with impaired cognition. Gut microbiota can modulate host brain function and behavior via …

[HTML][HTML] Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

[HTML][HTML] Microbiota-gut-brain axis and the central nervous system

X Zhu, Y Han, J Du, R Liu, K Jin, W Yi - Oncotarget, 2017 - ncbi.nlm.nih.gov
The gut and brain form the gut-brain axis through bidirectional nervous, endocrine, and
immune communications. Changes in one of the organs will affect the other organs …

[HTML][HTML] The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer's disease: A narrative review

E Aaldijk, Y Vermeiren - Ageing Research Reviews, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia, accounting for more than
50 million patients worldwide. Current evidence suggests the exact mechanism behind this …

[HTML][HTML] Increased microglial exosomal miR-124-3p alleviates neurodegeneration and improves cognitive outcome after rmTBI

X Ge, M Guo, T Hu, W Li, S Huang, Z Yin, Y Li, F Chen… - Molecular Therapy, 2020 - cell.com
Repetitive mild traumatic brain injury (rmTBI) is considered to be an important risk factor for
long-term neurodegenerative disorders such as Alzheimer's disease, which is characterized …