Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …

Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …

The liver controls the systemic exposure of amino acids entering via the gastro-intestinal
tract. For most amino acids except branched chain amino acids, hepatic uptake is very …

Neurons are metabolically handicapped in the sense that they are not able to perform de
novo synthesis of neurotransmitter glutamate and γ‐aminobutyric acid (GABA) from glucose …

The transport of amino acids in kidney and intestine is critical for the supply of amino acids to
all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number …

The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family
resemble the classically-described System A and System N transport activities in terms of …

The gold standard for studies of glutamate–glutamine (GABA) cycling and its connections to
brain biosynthesis from glucose of glutamate and GABA and their subsequent metabolism …

While transport processes for amino acids and glucose have long been known to be
expressed in the luminal and abluminal membranes of the endothelium comprising the …

Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …

Transporters of the SLC38 family are found in all cell types of the body. They mediate Na+-
dependent net uptake and efflux of small neutral amino acids. As a result they are …