Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Stroke is the second leading cause of mortality and the major cause of adult physical
disability worldwide. The currently available treatment to recanalize the blood flow in acute …

Ethnopharmacological relevance Rehmannioside A is derived from Rehmannia glutinosa
Libosch, which is widely used as an important ingredient in diverse traditional Chinese …

Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process
of multiple neurological disorders such as ischemic stroke, yet lacks effective therapeutic …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

Angiogenesis is an intricately regulated phenomenon. Its mechanisms in the ischemic brain
have not been clearly elucidated. The authors investigated expression of angiogenesis …

Myocardial ischemia/reperfusion injury (MIRI) is the major cause of myocardial cell damage
in acute myocardial infarction, and its treatment remains a clinical challenge. Ginsenoside …

Hypoxia is a critical factor for cell death or survival in ischemic stroke, but the pathological
consequences of combined ischemia-hypoxia are not fully understood. Here we examine …

Oxidative damage plays a critical role in many diseases of the central nervous system. This
study was conducted to determine the molecular mechanisms involved in the putative anti …

There is increasing evidence that some neuronal death after brain ischaemia is mediated by
the action of cysteine-requiring aspartate-directed proteases (caspases), the proteases …