The acquisition of genetic alterations, clonal evolution, and the tumor microenvironment
promote cancer progression, metastasis and therapy resistance. These events correspond …

In addition to their role in providing cellular energy, mitochondria fulfill a key function in
cellular calcium management. The present review provides an integrative view of cellular …

Current treatments for acute myeloid leukemia (AML) are often ineffective in eliminating
leukemic stem cells (LSCs), which perpetuate the disease. Here, we performed a metabolic …

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) signaling have
been shown to be dysregulated in multiple cancer types. Glucose regulatory protein 78 …

Photodynamic therapy (PDT) is an effective and promising cancer treatment. PDT directly
generates reactive oxygen species (ROS) through photochemical reactions. This oxygen …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

In order to proliferate in unfavourable conditions, cancer cells can take advantage of the
naturally occurring endoplasmic reticulum-associated unfolded protein response (UPR) via …

Glioblastoma is a difficult-to-cure disease owing to its malignancy. Under normal
circumstances, cancer is dependent on the glycolytic system for growth, and mitochondrial …

Cancer cells experience endoplasmic reticulum (ER) stress due to activated oncogenes and
conditions of nutrient deprivation and hypoxia. The ensuing unfolded protein response …

Glioblastoma, a malignant tumor, has no curative treatment. Recently, mitochondria have
been considered a potential target for treating glioblastoma. Previously, we reported that …