The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the
number of proteins predicted by DNA coding capacities owing to directed posttranslational …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

Successful control of falciparum malaria depends greatly on treatment with artemisinin
combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged …

The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and
hypotheses on the key aspects of the evolution of life on earth in light of comparative …

Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …

The dipeptide boronic acid bortezomib, also termed VELCADE®, is a proteasome inhibitor
now in use for the treatment of multiple myeloma, and its use for the treatment of other …

Principles of intracellular protein synthesis and protein degradation remain to be among the
most challenging questions of modern cell biology. Proteolysis plays an important role in …

Reactive oxygen species (ROS) are generated constantly within cells at low concentrations
even under physiological conditions. During aging the levels of ROS can increase due to a …

The AAA+ superfamily is a large and functionally diverse superfamily of NTPases that are
characterized by a conserved nucleotide-binding and catalytic module, the AAA+ module …

The crystal structures of the yeast 20S proteasome core particle (CP) in complex with
Salinosporamides A (NPI-0052; 1) and B (4) were solved at< 3 Å resolution. Each ligand is …