Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of
disease and no available disease-modifying treatments. Symptomatic early-stage OA of the …

Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive
destruction of articular cartilage. The etiology of OA is complex and involves a variety of …

Chondral and osteochondral lesions due to injury or other pathology commonly result in the
development of osteoarthritis, eventually leading to progressive total joint destruction …

Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage
regeneration. However, most studies focused on focal cartilage defect through surgical …

Articular cartilage was predicted to be one of the first tissues to successfully be regenerated,
but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has …

Background: Matrix-based cell therapy improves surgical handling, increases patient
comfort, and allows for expanded indications with better reliability within the knee joint. Five …

Osteoarthritis (OA) is one of the most common causes of disability around the globe,
especially in aging populations. The main symptoms of OA are pain and loss of motion and …

Background: The surfaces of the bones in the knee are covered with articular cartilage, a
rubber-like substance that is very smooth, allowing frictionless movement in the joint and …

Adult articular cartilage exhibits little capacity for intrinsic repair, and thus even minor injuries
or lesions may lead to progressive damage and osteoarthritic joint degeneration, resulting in …