Navigation through the bulk tumour, entry into the blood vasculature, survival in the
circulation, exit at distant sites and resumption of proliferation are all steps necessary for …

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues
and show great functional diversity. They have roles in development, homeostasis, tissue …

Breast cancer cells disseminate through TIE2/MENACalc/MENAINV-dependent cancer cell
intravasation sites, called tumor microenvironment of metastasis (TMEM), which are …

Metastasis is the leading cause of cancer-related deaths; metastatic lesions develop from
disseminated cancer cells (DCCs) that can remain dormant. Metastasis-initiating cells are …

Dissemination of tumor cells is an essential step in metastasis. Direct contact between a
macrophage, mammalian-enabled (MENA)–overexpressing tumor cell, and endothelial cell …

Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic
behavior and induction mechanisms of CSCs are not well understood. Here, we employ …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are
poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor …

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an
essential component of tumour dissemination during progression and metastasis. This …

Tumor-associated macrophages (TAMs) are critical for tumor metastasis. Two TAM subsets
support cancer cell intravasation: migratory macrophages guide cancer cells toward blood …

In the transgenic multicolor labeling strategy called'Brainbow', Cre-loxP recombination is
used to create a stochastic choice of expression among fluorescent proteins, resulting in the …