Authors of systematic reviews may perform subgroup analyses to investigate how treatment
effect varies across different subgroups of patients or trials. Previous research has shown …

Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Background The World Health Organization recommends uncomplicated P. falciparum
malaria is treated using Artemisinin‐based Combination Therapy (ACT). This review aims to …

Background Artemether-lumefantrine (AL) is a major and highly effective artemisinin-based
combination therapy that is becoming increasingly important as a new first-line therapy …

A 35-year-old man presents with a febrile illness after travel in West Africa, and severe
malaria is diagnosed. Treatment with artesunate is recommended. Artesunate is a member …

Background Artemether–lumefantrine and artesunate–amodiaquine are used as first-line
artemisinin-based combination therapies (ACTs) in west Africa. Pyronaridine–artesunate …

Background Artemisinin combination therapies (ACTs) are currently the preferred option for
treating uncomplicated malaria. Dihydroartemisinin-piperaquine (DHA-PQP) is a promising …

Background Uganda recently adopted artemether-lumefantrine (AL) as the recommended
first-line treatment for uncomplicated malaria. However, AL has several limitations, including …

Malaria, particularly that one caused by Plasmodium falciparum, remains a serious health
problem in Africa, South America, and many parts of Asia where it afflicts about 500 million …