Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged
mitochondria and the production of reactive oxygen species (ROS). The relationship …

How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired
neuronal bioenergetics and neuroinflammation are thought to play key roles in the …

Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Background & Aims Hepatocellular carcinoma (HCC), a leading cause of cancer-related
death, is associated with viral hepatitis, non-alcoholic steatohepatitis (NASH), and alcohol …

According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …