As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the
knowledge of its mechanism of action, various treatment modalities have been developed …

Background Accumulating studies have revealed that aberrant expression of circular RNAs
(circRNAs) is widely involved in the tumorigenesis and progression of malignant cancers …

Ferroptosis, a form of regulated cell death, is characterized by an excessive degree of iron
accumulation and lipid peroxidation. Although it was originally identified only in cells …

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …

PLAGL2 is upregulated in various tumors, including bladder cancer (BCa). However, the
mechanisms underlying the tumorigenic effects of PLAGL2 in BCa remain unclear. In our …

Glucose sensing and metabolic adaptation to glucose availability in the tumor
microenvironment are critical for cancer development. Here we show that HKDC1, a …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

The transcription factor family activator protein 2 (TFAP2) is vital for regulating both
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …

Background Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-
associated mortality. However, molecular mechanisms involved in ccRCC metastasis …