Background Alzheimer's disease (AD) is the commonest cause of dementia, with
approximately 5 million new cases occurring annually. Despite decades of research, its …

Worldwide there are over 46 million people living with dementia, and this number is
expected to double every 20 years reaching about 131 million by 2050. The cost to the …

Background and purpose Parkinson disease (PD) presents relevant sex‐related differences
in epidemiology, pathophysiology, and clinical features, with males being more vulnerable …

Reduction in testosterone levels in men during aging is associated with cognitive decline
and risk of dementia. Animal studies have shown benefits for testosterone supplementation …

Abstract Alzheimer's disease (AD), the commonest progressive neurodegenerative disorder
of the brain, is clinically characterized by the formation of extracellular amyloid plaques and …

Human life expectancy and the number of the oldest old are rapidly increasing worldwide.
Advanced age is the main risk factor for dementia, representing one of the major causes of …

Pervasive age-related dysfunction in hypothalamic-pituitary-gonadal (HPG) axis is
associated with cognitive impairments in aging as well as pathogenesis of age-related …

By maintaining the Na+ and K+ transmembrane gradient mammalian Na, K-ATPase acts as
a key regulator of neuronal electrotonic properties. Na, K-ATPase has an important role in …

Alzheimers' disease (AD) is the most common cause of dementia, with an estimated 5
million new cases occurring annually. Among the elderly, AD shortens life expectancy …

Age-related androgen depletion has been implicated in compromised neuroprotection and
is involved in the pathogenesis of neurodegenerative disease, including Alzheimer's …