Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Bone tumors are a rare and heterogeneous group of neoplasms that occur in the bone. The
diversity and considerable morphologic overlap of bone tumors with other mesenchymal …

Highlights•This Clinical Practice Guideline provides key recommendations on the
management of bone sarcomas.•Recommendations have been agreed following a …

Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

Primary bone tumours are rare, accounting for< 0.2% of malignant neoplasms registered in
the EUROCARE (European Cancer Registry based study on survival and care of cancer …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

The fifth edition of the World Health Organization (WHO) classification of soft tissue and
bone tumours was published in May 2020. This 'Blue Book', which is also available digitally …

The 4th edition of the World Health Organization's Classification of Head and Neck Tumours
was published in January of 2017. This article provides a summary of the changes to …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …