New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …

The diarylurea is a scaffold of great importance in medicinal chemistry as it is present in
numerous heterocyclic compounds with antithrombotic, antimalarial, antibacterial, and anti …

Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric
features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised …

Inhibition of angiogenesis is a promising strategy for the treatment of cancer. Herein, we
describe the design and synthesis of thieno [2, 3-d] pyrimidine-1, 3, 4-thiadiazole-aryl urea …

Herein, we have carried out a structural optimization campaign to discover the novel anti-
tumor agents with our previously screened YQY-26 as the hit compound. A library of thirty …

The antitumor activity of newly synthesized 4-anilino-2-vinylquinazolines 8a-r was measured
comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated …

Type 2 diabetes mellitus is a complex metabolic disorder requiring polypharmacology
approaches for effective treatment. Combinatorial library of fifteen new tricyclic …

The diaryl urea is an important fragment/pharmacophore in constructing anticancer
molecules due to its near-perfect binding with certain acceptors. The urea NH moiety is a …

The previously reported structures of oxytrofalcatins B and C possess a benzoyl indole core.
However, following synthesis and NMR comparison of both the proposed structure and the …

Inhibition of VEGFR-2 kinase has been highlighted as one of the well-defined strategies to
suppress tumor growth via blockade of angiogenesis. Guided by the principles of …