Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the “next
generation” of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the …

Investigators developed chimeric antigen receptors (CAR s) for expression on T cells more
than 25 years ago. When the CAR is derived from an antibody, the resultant cell should …

Malignant gliomas, the most common type of primary brain tumor in adults, are associated
with disproportionate cancer-related morbidity and mortality. Recently, there have been …

The purpose of the National Cancer Institute pilot project to prioritize cancer antigens was to
develop a well-vetted, priority-ranked list of cancer vaccine target antigens based on …

Purpose: Rindopepimut is a vaccine targeting the tumor-specific EGF driver mutation,
EGFRvIII. The ReACT study investigated whether the addition of rindopepimut to standard …

Background: Glioblastoma multiforme (GBM) is the most common and lethal primary
malignancy of the central nervous system (CNS). Despite the proven benefit of surgical …

The magnetic nanoparticle has emerged as a potential multifunctional clinical tool that can
provide cancer cell detection by magnetic resonance imaging (MRI) contrast enhancement …

Glioblastoma is the most common and most malignant primary adult human brain tumour.
Diagnosis of glioblastoma carries a dismal prognosis. Treatment resistance and tumour …

Generating responses to tumor antigens poses a challenge for immunotherapy. This phase
II trial (NCT02129075) tested fms-like tyrosine kinase 3 (Flt3) ligand pre-treatment …

Epidermal growth factor receptor (EGFR) and EGFRvIII analysis is of current interest in
glioblastoma–the most common malignant primary CNS tumor, because of new EGFRvIII …