microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …

Gliomas make up approximately 30% of all brain and central nervous system tumors and
80% of all malignant brain tumors. Despite the frequency of gliomas, the etiology of these …

Despite aggressive multimodal treatment, glioblastoma (GBM), a grade IV primary brain
tumor, still portends a poor prognosis with a median overall survival of 12–16 months. The …

Abstract miRNAs act as oncogenes or tumor suppressors in a wide variety of human
cancers, including prostate cancer (PCa). We found a severe and consistent downregulation …

The mir-34 family was originally cloned and characterized in 2007 as a p53 target gene.
Almost immediately it became clear that its major role is as a master regulator of tumor …

The homeobox (HOX) genes encoding an evolutionarily highly conserved family of
homeodomain-containing transcriptional factors are essential for embryogenesis and …

Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain,
remaining incurable with a median survival time of only 15 months. In an effort to identify …

Glioblastoma is the most aggressive brain tumor and, even with the current multimodal
therapy, is an invariably lethal cancer with a life expectancy that depends on the tumor …

MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …

Glioblastoma (GBM) is the most common malignant adult brain cancer with no curative
treatment strategy. A significant hurdle in GBM treatment is effective therapeutic delivery to …