Prothymosin alpha (ProTα) was discovered to be a necrosis inhibitor from the conditioned
medium of a primary culture of rat cortical neurons under starved conditions. This protein …

Background: Multiple sclerosis (MS) afflicts more than 2.5 million individuals worldwide and
this number is increasing over time. Within the past years, a great number of disease …

Background Cisplatin-based chemotherapy is the first line of treatment for bladder cancer.
However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia …

Prothymosin‐alpha protects the brain and retina from ischemic damage. Although
prothymosin‐alpha contributes to toll‐like receptor (TLR 4)‐mediated immnunopotentiation …

Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary
disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the …

Human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (hiPSC-
RPE) cells suspension have the potential for regenerative treatment. However, practical …

Background: Obesity constitutes a chronic, low-grade inflammatory status that predisposes
people to the development of insulin resistance and cardiometabolic complications …

High-mobility group box 1 (HMGB1) is increased in the cerebrospinal fluid (CSF) and serum
during the early and late phases of brain ischemia and is known to contribute to brain …

Prothymosin alpha (ProTα) has robustness roles against brain and retinal ischemia or serum-
starvation stress. In the ProTα sequence, the active core 30-amino acid peptide/P 30 (aa 49 …

Athero-thrombosis of the arteries supplying the brain and lower limb are the main causes of
stroke and limb loss. New therapies are needed to improve the outcomes of athero …