Directed genome evolution simulates the process of natural evolution at the genomic level in
the laboratory to generate desired phenotypes. Here we review the applications of recent …

Microbes are increasingly employed as cell factories to produce biomolecules. This often
involves the expression of complex heterologous biosynthesis pathways in host strains …

Pigments are widely used in the food, cosmetic, textile, pharmaceutical, and materials
industries. Demand for natural pigments has been increasing due to concerns regarding …

With the completion of Sc2. 0 chromosomes, synthetic chromosome rearrangement and
modification by loxP-mediated evolution (SCRaMbLE) becomes more critical for in-depth …

Microbial production of monoterpenoid indole alkaloids (MIAs) provides a sustainable and
eco‐friendly means to obtain compounds with high pharmaceutical values. However …

Lycopene has been widely used in the food industry and medical field due to its antioxidant,
anti-cancer, and anti-inflammatory properties. However, achieving efficient manufacture of …

Because of its potent antioxidant effects, lycopene has been used in various industries
including, but not limited to, food, medical, and cosmetic industries. Yarrowia lipolytica, a …

Genomic rearrangements play a crucial role in shaping biological phenotypic diversity and
driving species evolution. Synthetic chromosome rearrangement and modification by LoxP …

“合成生命, 设计生命” 是合成生物学与生物制造的重要使命, 通过按需设计, 化学再造人工基因组,
实现人工细胞工厂的精准构建. 当前细胞工厂面临代谢网络复杂, 缺乏理性设计, 试错成本高 …

Development of genome editing tools based on chimeric nucleases have led us to target
and modify specific genome sequences with high precision. These sequence specific …