Pheochromocytoma and paraganglioma

HPH Neumann, WF Young Jr… - New England journal of …, 2019 - Mass Medical Soc
Pheochromocytoma and Paraganglioma Pheochromocytoma and paraganglioma are
related tumors that differ mainly in location; pheochromocytomas are adrenal, and …

[HTML][HTML] Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

C Wigerup, S Påhlman, D Bexell - Pharmacology & therapeutics, 2016 - Elsevier
Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

[HTML][HTML] Comprehensive molecular characterization of pheochromocytoma and paraganglioma

L Fishbein, I Leshchiner, V Walter, L Danilova… - Cancer cell, 2017 - cell.com
We report a comprehensive molecular characterization of pheochromocytomas and
paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that …

Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline

JWM Lenders, QY Duh, G Eisenhofer… - The Journal of …, 2014 - academic.oup.com
Objective: The aim was to formulate clinical practice guidelines for pheochromocytoma and
paraganglioma (PPGL). Participants: The Task Force included a chair selected by the …

Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity

PLM Dahia - Nature Reviews Cancer, 2014 - nature.com
The neuroendocrine tumours pheochromocytomas and paragangliomas carry the highest
degree of heritability in human neoplasms, enabling genetic alterations to be traced to …

An overview of 20 years of genetic studies in pheochromocytoma and paraganglioma

A Buffet, N Burnichon, J Favier… - Best practice & research …, 2020 - Elsevier
Paragangliomas and pheochromocytomas (PPGL) are rare neuroendocrine tumours
characterized by a strong genetic determinism. Over the past 20 years, evolution of PPGL …

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity

EU Hammarlund, E Flashman, S Mohlin, F Licausi - Science, 2020 - science.org
BACKGROUND Animals and land plants are the most diverse complex multicellular life-
forms on Earth, and their success intricately links a capacity for adhering cells to perform …

Consensus statement on next-generation-sequencing-based diagnostic testing of hereditary phaeochromocytomas and paragangliomas

NGS in PPGL (NGSnPPGL) Study Group… - Nature Reviews …, 2017 - nature.com
Phaeochromocytomas and paragangliomas (PPGLs) are neural-crest-derived tumours of
the sympathetic or parasympathetic nervous system that are often inherited and are …

JAK2 unmutated erythrocytosis: current diagnostic approach and therapeutic views

N Gangat, N Szuber, A Pardanani, A Tefferi - Leukemia, 2021 - nature.com
JAK2 unmutated or non-polycythemia vera (PV) erythrocytosis encompasses both hereditary
and acquired conditions. A systematic diagnostic approach begins with documentation of …

Characteristics of Pediatric vs Adult Pheochromocytomas and Paragangliomas

C Pamporaki, B Hamplova, M Peitzsch… - The Journal of …, 2017 - academic.oup.com
Abstract Context: Pheochromocytomas and paragangliomas (PPGLs) in children are often
hereditary and may present with different characteristics compared with adults. Hereditary …