Many coordination complexes and organometallic compounds with the 4d6 and 5d6
valence electron configurations have outstanding photophysical and photochemical …

The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …

The endoplasmic reticulum (ER) has recently emerged as a promising target for anticancer
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …

Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

This review focuses on cytotoxic rhenium compounds in terms of IC 50 values, their mode of
action in biological systems and their status in clinical trials. Biological studies of different …

Phosphorescent metal complexes are a new kind of multifunctional antitumor compounds
that can integrate imaging and antitumor functions in a single molecule. In this minireview …

Eight rhenium (I) tricarbonyl aqua complexes with the general formula fac-[Re (CO) 3 (N,
N′-bid)(H2O)][NO3](1–8), where N, N′-bid is (2, 6-dimethoxypyridyl) imidazo [4, 5-f] 1, 10 …

Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …

Fragment-based drug discovery (FBDD) is a powerful strategy for the identification of new
bioactive molecules. FBDD relies on fragment libraries, generally of modest size, but of high …