[HTML][HTML] Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

A Vezzani, S Balosso, T Ravizza - Nature Reviews Neurology, 2019 - nature.com
Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Anakinra therapy for non-cancer inflammatory diseases

G Cavalli, CA Dinarello - Frontiers in pharmacology, 2018 - frontiersin.org
Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-
1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory …

Glia and epilepsy: excitability and inflammation

O Devinsky, A Vezzani, S Najjar, NC De Lanerolle… - Trends in …, 2013 - cell.com
Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and
hypersynchrony of brain neurons. Current theories of pathophysiology stress neuronal …

Cytokines in new‐onset refractory status epilepticus predict outcomes

A Hanin, J Cespedes, K Dorgham, Y Pulluru… - Annals of …, 2023 - Wiley Online Library
Objective The objective of this study was to investigate inflammation using cerebrospinal
fluid (CSF) and serum cytokines/chemokines in patients with new‐onset refractory status …

Inflammatory mediators in human epilepsy: a systematic review and meta-analysis

EE de Vries, B van den Munckhof, KPJ Braun… - Neuroscience & …, 2016 - Elsevier
Background Accumulating evidence suggests a role for inflammation in the pathophysiology
of epilepsy. Methods We performed a systematic review and meta-analysis of studies that …

Anti-inflammatory small molecules to treat seizures and epilepsy: from bench to bedside

A Dey, X Kang, J Qiu, Y Du, J Jiang - Trends in pharmacological sciences, 2016 - cell.com
As a crucial component of brain innate immunity, neuroinflammation initially contributes to
neuronal tissue repair and maintenance. However, chronic inflammatory processes within …

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

E Aronica, S Bauer, Y Bozzi, M Caleo, R Dingledine… - …, 2017 - Wiley Online Library
A large body of evidence that has accumulated over the past decade strongly supports the
role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory …

The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches

M Lévesque, G Biagini, M de Curtis… - Neuroscience & …, 2021 - Elsevier
Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

In vitro blood–brain barrier models: current and perspective technologies

P Naik, L Cucullo - Journal of pharmaceutical sciences, 2012 - Elsevier
Even in the 21st century, studies aimed at characterizing the pathological paradigms
associated with the development and progression of central nervous system diseases are …

[引用][C] Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options

W Löscher, H Potschka, SM Sisodiya, A Vezzani - Pharmacological reviews, 2020 - ASPET