Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form
channels across the nuclear envelope. They are large macromolecular assemblies with a …

Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary
transport gates for molecular exchange between nucleus and cytoplasm. Stripping the …

Abstract The GGGGCC (G4C2) repeat expansion in a noncoding region of C9orf72 is the
most common cause of sporadic and familial forms of amyotrophic lateral sclerosis and …

Defects in the architecture or integrity of the nuclear envelope are associated with a variety
of human diseases. Micronuclei, one common nuclear aberration, are an origin for …

As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

Biogenesis of nuclear pore complexes (NPCs) includes the formation of the permeability
barrier composed of phenylalanine-glycine-rich nucleoporins (FG-Nups) that regulate the …

HIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the
retroviral preintegration complex (PIC), into the nucleus. Too large for passive diffusion …

In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and
reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic …

In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and
translation in the cytoplasm imposes the requirement of transporting thousands of …