Influenza virus contains a single-stranded negative-sense RNA genome. Replication of the
genome is carried out by the viral RNA-dependent RNA polymerase in the context of the …

RNA viruses include many important human and animal pathogens, such as the influenza
viruses, respiratory syncytial virus, Ebola virus, measles virus and rabies virus. The …

Chickens genetically resistant to avian influenza could prevent future outbreaks. In chickens,
influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to …

Abstract Human ANP32A and ANP32B are essential but redundant host factors for influenza
virus genome replication. While most influenza viruses cannot replicate in edited human …

Influenza polymerase (FluPol) transcribes viral mRNA at the beginning of the viral life cycle
and initiates genome replication after viral protein synthesis. However, it remains poorly …

Aquatic birds represent a vast reservoir from which new pandemic influenza A viruses can
emerge. Influenza viruses contain a negative-sense segmented RNA genome that is …

Bunyaviruses are negative sense, single-strand RNA viruses that infect a wide range of
vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority …

Transcription and replication of the influenza virus RNA genome is catalyzed by the viral
heterotrimeric RNA-dependent RNA polymerase in the context of viral ribonucleoprotein …

The emergence of previously unknown disease-causing viruses in mammals is in part the
result of a long-term evolutionary process. Reconstructing the deep phylogenetic histories of …

Influenza polymerase uses unique mechanisms to synthesize capped and polyadenylated
mRNAs from the genomic viral RNA (vRNA) template, which is packaged inside …