One of the major challenges in preclinical studies of alcohol abuse and dependence
remains the development of paradigms that will elicit high ethanol intake and mimic the …

Alcohol use disorders (AUD) are defined as alcohol abuse and alcohol dependence, which
create large problems both for society and for the drinkers themselves. To date, no …

Compulsive drinking despite serious adverse medical, social and economic consequences
is a characteristic of alcohol use disorders in humans. Although frontal cortical areas have …

Continued seeking and drinking of alcohol despite adverse legal, health, economic, and
societal consequences is a central hallmark of human alcohol use disorders. This …

A complex relationship exists between alcohol-drinking behavior and stress. Alcohol has
anxiety-reducing properties and can relieve stress, while at the same time acting as a …

Alcohol consumption afflicts men and women differently. However, the underlying neuronal
mechanisms that contribute to the difference are mostly unexplored. Although more men …

Compulsion-like alcohol drinking (CLAD), where consumption continues despite negative
consequences, is a major obstacle to treating alcohol use disorder. The locus coeruleus …

The paraventricular nucleus of the thalamus (PVT) has been shown to participate in hedonic
feeding and is thought to influence drug seeking. This understudied nucleus contains …

Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the
global disease burden, contributes substantially to societal and economic costs, and leads …

Alcohol Use Disorder (AUD) ranks among the most prevalent mental disorders, extracting~
$250 billion/year in the US alone and producing myriad medical and social harms. Also, the …