Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

Background Chronic graft-versus-host disease (GVHD), a major complication of allogeneic
stem-cell transplantation, becomes glucocorticoid-refractory or glucocorticoid-dependent in …

Background Acute graft-versus-host disease (GVHD) remains a major limitation of
allogeneic stem-cell transplantation; not all patients have a response to standard …

When T cells from a bone marrow donor begin to attack the host within 3 months after
hematopoietic-cell transplantation, acute graft-versus-host disease results. The disease …

Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell
transplantation, is characterized by infections and debilitating tissue injury leading to …

The intestinal microbiome is a signalling hub that integrates environmental inputs, such as
diet, with genetic and immune signals to affect the host's metabolism, immunity and …

The exposure of cells, tissues and extracellular matrix to harmful reactive species causes a
cascade of reactions and induces activation of multiple internal defence mechanisms …

The development of human gut microbiota begins as soon as the neonate leaves the
protective environment of the uterus (or maybe in-utero) and is exposed to innumerable …

Intestinal bacteria may modulate the risk of infection and graft-versus-host disease (GVHD)
after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT recipients …