Chromatin immunoprecipitation experiments followed by sequencing (ChIP–seq) detect
protein–DNA binding events and chemical modifications of histone proteins. Challenges in …

Computationally predicting drug–target interactions is useful to select possible drug (or
target) candidates for further biochemical verification. We focus on machine learning-based …

Nucleotide sequence and taxonomy reference databases are critical resources for
widespread applications including marker-gene and metagenome sequencing for …

SARS-CoV-2 is a betacoronavirus with a single-stranded, positive-sense, 30-kilobase RNA
genome responsible for the ongoing COVID-19 pandemic. Although population average …

Challenges in cultivating microorganisms have limited the phylogenetic diversity of currently
available microbial genomes. This is being addressed by advances in sequencing …

Evolution provides the unifying framework with which to understand biology. The coherent
investigation of genic and genomic data often requires comparative genomics analyses …

Polymerase chain reaction (PCR) is a basic molecular biology technique with a multiplicity
of uses, including deoxyribonucleic acid cloning and sequencing, functional analysis of …

Residue-residue coevolution has been observed across a number of protein-protein
interfaces, but the extent of residue coevolution between protein families on the whole …

Chaperones are central to the proteostasis network (PN) and safeguard the proteome from
misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 …

Abstract The BiGG Models knowledge base (http://bigg. ucsd. edu) is a centralized
repository for high-quality genome-scale metabolic models. For the past 12 years, the …