[HTML][HTML] Metazoan micrornas
DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
MicroRNAs as regulatory elements in immune system logic
A Mehta, D Baltimore - Nature Reviews Immunology, 2016 - nature.com
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …
decisions. They act by negatively regulating the expression of key immune development …
MiRNA-210: a current overview
microRNAs (miRNAs) are a group of highly conserved small non-coding RNAs that were
found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating …
found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating …
MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy
Neuroinflammation is a major contributor to secondary neuronal injury that accounts for a
significant proportion of final brain cell loss in neonatal hypoxic-ischemic encephalopathy …
significant proportion of final brain cell loss in neonatal hypoxic-ischemic encephalopathy …
Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210
The microRNA miR-210 is a signature of hypoxia. We found robust increase in the
abundance of miR-210 (> 100-fold) in activated T cells, especially in the TH17 lineage of …
abundance of miR-210 (> 100-fold) in activated T cells, especially in the TH17 lineage of …
Genetic and hypoxic alterations of the micro RNA‐210‐ISCU 1/2 axis promote iron–sulfur deficiency and pulmonary hypertension
Abstract Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their
regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that …
regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that …
Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells
Hypoxia is a common hallmark of healthy tissues in physiological states or chronically
inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly …
inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly …
MicroRNAs: Tiny regulators of gene expression with pivotal roles in normal B-Cell development and B-Cell chronic lymphocytic leukemia
Simple Summary The involvement of miRNAs in physiological cellular processes has been
well documented. The development of B cells, which is dictated by a miRNA-transcription …
well documented. The development of B cells, which is dictated by a miRNA-transcription …
MicroRNA regulation of lymphocyte tolerance and autoimmunity
LJ Simpson, KM Ansel - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Understanding the cell-intrinsic cues that permit self-reactivity in lymphocytes, and therefore
autoimmunity, requires an understanding of the transcriptional and posttranscriptional …
autoimmunity, requires an understanding of the transcriptional and posttranscriptional …
miRNA-mediated control of B cell responses in immunity and SLE
SL Schell, ZSM Rahman - Frontiers in immunology, 2021 - frontiersin.org
Loss of B cell tolerance is central to autoimmune diseases such as systemic lupus
erythematosus (SLE). As such, the mechanisms involved in B cell development, maturation …
erythematosus (SLE). As such, the mechanisms involved in B cell development, maturation …