[HTML][HTML] An overview of autoantibodies in rheumatoid arthritis

MAM van Delft, TWJ Huizinga - Journal of autoimmunity, 2020 - Elsevier
Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …

Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis

D van der Woude, AHM van der Helm-van - Best practice & research …, 2018 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation,
which affects approximately 1% of the population. The benefit of early recognition and …

[HTML][HTML] The role of autoantibodies in the pathophysiology of rheumatoid arthritis

V Derksen, TWJ Huizinga… - Seminars in …, 2017 - Springer
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation.
The presence of autoantibodies in the sera of RA patients has provided many clues to the …

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology

M Volkov, KA van Schie… - Immunological …, 2020 - Wiley Online Library
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In
the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly …

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis

LA Trouw, T Rispens, REM Toes - Nature Reviews Rheumatology, 2017 - nature.com
The presence of autoantibodies is one of the hallmarks of rheumatoid arthritis (RA). In the
past few decades, rheumatoid factors (autoantibodies that recognize the Fc-tail of …

Neutrophil extracellular trap-associated carbamylation and histones trigger osteoclast formation in rheumatoid arthritis

LJ O'Neil, CB Oliveira, X Wang, M Navarrete… - Annals of the …, 2023 - ard.bmj.com
Objective Neutrophil infiltration into the synovial joint is a hallmark of rheumatoid arthritis
(RA), a disease characterised by progressive bone erosion. However, the mechanisms by …

Guidelines for biomarkers in autoimmune rheumatic diseases-evidence based analysis

R Giacomelli, A Afeltra, A Alunno, E Bartoloni-Bocci… - Autoimmunity …, 2019 - Elsevier
Autoimmune rheumatic diseases are characterised by an abnormal immune system
response, complement activation, cytokines dysregulation and inflammation. In last years …

Bone loss in rheumatoid arthritis: basic mechanisms and clinical implications

J Shim, Z Stavre, EM Gravallese - Calcified Tissue International, 2018 - Springer
Patients with rheumatoid arthritis (RA) have historically developed progressive damage of
articular bone and cartilage, which correlates with disability over time. In addition, these …

Triple positivity for anti–citrullinated protein autoantibodies, rheumatoid factor, and anti–carbamylated protein antibodies conferring high specificity for rheumatoid …

MK Verheul, S Böhringer, MAM van Delft… - Arthritis & …, 2018 - Wiley Online Library
Objective In rheumatoid arthritis (RA), anti–citrullinated protein antibodies (ACPA s) and
rheumatoid factor (RF) are commonly used to aid in the diagnosis. Although these …

[HTML][HTML] ACPA-negative rheumatoid arthritis: From immune mechanisms to clinical translation

K Li, M Wang, L Zhao, Y Liu, X Zhang - EBioMedicine, 2022 - thelancet.com
The presence of anti-citrullinated protein autoantibodies (ACPA) is a hallmark feature of
rheumatoid arthritis (RA), which causes chronic joint destruction and systemic inflammation …