Fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) are commonly
used as MRI biomarkers of white matter microstructure in diffusion MRI studies of …

Damage to myelin is a key feature of multiple sclerosis (MS) pathology. Magnetic resonance
imaging (MRI) has revolutionized our ability to detect and monitor MS pathology in vivo …

Abstract Inhomogeneous Magnetization Transfer (ihMT) is a development from the MT MRI
technique. IhMT can be considered as a dipolar order relaxation time (T 1D) weighted …

Background The g-ratio, quantifying the comparative thickness of the myelin sheath
encasing an axon, is a geometrical invariant that has high functional relevance because of …

Background Myelin specific imaging techniques to characterize white matter in
demyelinating diseases such as multiple sclerosis (MS) have become an area of increasing …

Leukodystrophies constitute a large and heterogeneous group of genetic diseases primarily
affecting the white matter of the central nervous system. Different disorders target different …

Off‐resonance radio frequency irradiation can induce the ordering of proton spins in the
dipolar fields of their neighbors, in molecules with restricted mobility. This dipolar order …

Assessing the consistency of quantitative MRI measurements is critical for inclusion in
longitudinal studies and clinical trials. Intraclass coefficient correlation and coefficient of …

Purpose We investigated the correlation, reproducibility, and effect of white matter fiber
orientation for three myelin‐sensitive MRI techniques: magnetization transfer ratio (MTR) …

T 1 D, the relaxation time of dipolar order, is sensitive to slow motional processes. Thus T 1
D is a probe for membrane dynamics and organization that could be used to characterize …