Parasitic worms affect virus coinfection: a mechanistic overview

G Petrellis, O Piedfort, B Katsandegwaza… - Trends in …, 2023 - cell.com
Helminths are parasitic worms that coevolve with their host, usually resulting in long-term
persistence through modulating host immunity. The multifarious mechanisms altering the …

Preexisting helminth challenge exacerbates infection and reactivation of gammaherpesvirus in tissue resident macrophages

CM Zarek, C Dende, J Coronado, M Pendse… - PLoS …, 2023 - journals.plos.org
Even though gammaherpesvirus and parasitic infections are endemic in parts of the world,
there is a lack of understanding about the outcome of coinfection. In humans, coinfections …

Bringing Balance: Immune Interactions Regulating Murine Gammaherpesvirus 68 Latency

ST Majeed, CN Jondle - Current Clinical Microbiology Reports, 2024 - Springer
Abstract Purpose of Review Gammaherpesviruses constitute the chief virus family that is
capable of exhibiting true latency. Latency allows the viral genome to override host immune …

[HTML][HTML] Cytokine Dynamics and Herpesvirus Interactions in Pediatric Liver and Kidney Transplant Recipients: The Distinct Behavior of HCMV, HHV6, HHV7 and EBV

Y Sánchez-Ponce, JR Murillo-Eliosa… - Viruses, 2024 - mdpi.com
Pediatric solid organ transplant (SOT) recipients face a challenging balance between
immunosuppression and graft rejection. While Epstein–Barr Virus (EBV) and …

Nontypeable Haemophilus influenzae challenge during gammaherpesvirus infection enhances viral reactivation and latency

NP Huss, ST Majeed, BM Wills, VL Tarakanova… - Virology, 2024 - Elsevier
Gammaherpesviruses are ubiquitous, lifelong pathogens, associated with multiple cancers
that infect over 95% of the adult population. Increases in viral reactivation, due to stress and …

Coinfection with Intestinal Parasite Expands Resident Macrophages and Impairs Control of Chronic Herpesvirus Infection

CM Zarek, C Dende, J Coronado, M Pendse, P Dryden… - bioRxiv, 2022 - biorxiv.org
In addition to a range of homeostatic functions, resident macrophages are essential for
immune surveillance in tissues. Therefore, anything that alters the phenotype or function of …

[HTML][HTML] Murine Gammaherpesvirus 68 Efficiently Infects Myeloid Cells Resulting In An Atypical, Restricted Form Of Infection

G Vragel, BD Gomez, RE Kostelecky, KS Noell… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The gammaherpesviruses (γHVs) establish a lifelong infection in their hosts, with the cellular
outcome of infection intimately regulated by target cell type. Murine gammaherpesvirus 68 …

Age-associated B cells are long-lasting effectors that impede latent γHV68 reactivation

IC Mouat, I Shanina, MS Horwitz - Scientific Reports, 2022 - nature.com
Age-associated B cells (ABCs; CD19+ CD11c+ T-bet+) are a unique population that are
increased in an array of viral infections, though their role during latent infection is largely …

Age-associated B cells are long-lasting effectors that impede latent gHV68 reactivation

IC Mouat, I Shanina, MS Horwitz - 2022 - researchsquare.com
Age-associated B cells (ABCs; CD19+ CD11c+ T-bet+) are a unique population that are
increased in an array of viral infections, though their role during latent infection is largely …

Age-associated B cells are critical for the control of latent gammaherpesvirus 68 infection

IC Mouat, I Shanina, MS Horwitz - bioRxiv, 2021 - biorxiv.org
Age-associated B cells (ABCs; CD19+ CD11c+ T-bet+) are increased during an array of viral
infections, though their role during viral latency is unexplored. Here, we use murine …