Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby
producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Significance: Diabetic cardiomyopathy (DCM) is a frequent complication occurring even in
well-controlled asymptomatic diabetic patients, and it may advance to heart failure (HF) …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …

Cancer cells require increased levels of NADPH for increased nucleotide synthesis and for
protection from ROS. Recent studies show that increased NADPH is generated in several …

Nicotinamide adenine dinucleotide (NAD+) homeostasis is constantly compromised due to
degradation by NAD+‐dependent enzymes. NAD+ replenishment by supplementation with …

Compartmentalization is a fundamental design principle of eukaryotic metabolism. Here, we
review the compartmentalization of NAD+/NADH and NADP+/NADPH with a focus on the …

Nicotinamide adenine dinucleotide phosphate (NADP+) is essential for producing NADPH,
the primary cofactor for reductive metabolism. We find that growth factor signaling through …