Sulfonyl fluorides as targets and substrates in the development of new synthetic methods
The advent of sulfur (vi)-fluoride exchange (SuFEx) processes as transformations with click-
like reactivity has invigorated research into electrophilic species featuring a sulfur–fluorine …
like reactivity has invigorated research into electrophilic species featuring a sulfur–fluorine …
The growing applications of SuFEx click chemistry
SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions,
geared towards the rapid and reliable assembly of functional molecules. This review …
geared towards the rapid and reliable assembly of functional molecules. This review …
Advances in the construction of diverse SuFEx linkers
D Zeng, WP Deng, X Jiang - National Science Review, 2023 - academic.oup.com
Sulfur fluoride exchange (SuFEx), a new generation of click chemistry, was first presented by
Sharpless, Dong and co-workers in 2014. Owing to the high stability and yet efficient …
Sharpless, Dong and co-workers in 2014. Owing to the high stability and yet efficient …
Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO2
TSB Lou, Y Kawamata, T Ewing… - Angewandte Chemie …, 2022 - Wiley Online Library
Simple access to aryl sulfinates from aryl iodides and bromides is reported using an
inexpensive Ni‐electrocatalytic protocol. The reaction exhibits a broad scope, uses stock …
inexpensive Ni‐electrocatalytic protocol. The reaction exhibits a broad scope, uses stock …
Chemical and biology of sulfur fluoride exchange (SuFEx) click chemistry for drug discovery
Compounds containing an Ssingle bondF bond have garnered intense interest in the
chemical and biological literature. In particular, sulfonyl fluorides (RSO 2 F) are commonly …
chemical and biological literature. In particular, sulfonyl fluorides (RSO 2 F) are commonly …
Photoredox catalytic radical fluorosulfonylation of olefins enabled by a bench-stable redox-active fluorosulfonyl radical precursor
P Wang, H Zhang, X Nie, T Xu, S Liao - Nature Communications, 2022 - nature.com
Sulfonyl fluorides have attracted considerable and growing research interests from various
disciplines, which raises a high demand for novel and effective methods to access this class …
disciplines, which raises a high demand for novel and effective methods to access this class …
Electrochemical Oxo‐Fluorosulfonylation of Alkynes under Air: Facile Access to β‐Keto Sulfonyl Fluorides
D Chen, X Nie, Q Feng, Y Zhang… - Angewandte Chemie …, 2021 - Wiley Online Library
Radical fluorosulfonylation is emerging as an appealing approach for the synthesis of
sulfonyl fluorides, which have widespread applications in many fields, in particular in the …
sulfonyl fluorides, which have widespread applications in many fields, in particular in the …
Divergent sulfur (VI) fluoride exchange linkage of sulfonimidoyl fluorides and alkynes
D Zeng, Y Ma, WP Deng, M Wang, X Jiang - Nature Synthesis, 2022 - nature.com
Sulfur (VI) fluoride exchange reactions have been applied to the linkage of a diverse range
of molecules. However, the connectivity of fluorosulfuryls with alkynes remains a formidable …
of molecules. However, the connectivity of fluorosulfuryls with alkynes remains a formidable …
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We
report here a SuFEx-enabled, agnostic approach for the discovery and optimization of …
report here a SuFEx-enabled, agnostic approach for the discovery and optimization of …
Emerging building blocks for medicinal chemistry: recent synthetic advances
OO Grygorenko, DM Volochnyuk… - European Journal of …, 2021 - Wiley Online Library
Current medicinal chemistry relies heavily on the quality of building blocks, ie reagents used
to introduce chemical diversity into the target molecules. The last decade witnessed an …
to introduce chemical diversity into the target molecules. The last decade witnessed an …