Sulfonyl fluorides as targets and substrates in the development of new synthetic methods

TSB Lou, MC Willis - Nature Reviews Chemistry, 2022 - nature.com
The advent of sulfur (vi)-fluoride exchange (SuFEx) processes as transformations with click-
like reactivity has invigorated research into electrophilic species featuring a sulfur–fluorine …

The growing applications of SuFEx click chemistry

AS Barrow, CJ Smedley, Q Zheng, S Li… - Chemical Society …, 2019 - pubs.rsc.org
SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions,
geared towards the rapid and reliable assembly of functional molecules. This review …

Advances in the construction of diverse SuFEx linkers

D Zeng, WP Deng, X Jiang - National Science Review, 2023 - academic.oup.com
Sulfur fluoride exchange (SuFEx), a new generation of click chemistry, was first presented by
Sharpless, Dong and co-workers in 2014. Owing to the high stability and yet efficient …

Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO2

TSB Lou, Y Kawamata, T Ewing… - Angewandte Chemie …, 2022 - Wiley Online Library
Simple access to aryl sulfinates from aryl iodides and bromides is reported using an
inexpensive Ni‐electrocatalytic protocol. The reaction exhibits a broad scope, uses stock …

Chemical and biology of sulfur fluoride exchange (SuFEx) click chemistry for drug discovery

SW Lucas, RZ Qin, KP Rakesh, KSS Kumar, HL Qin - Bioorganic Chemistry, 2023 - Elsevier
Compounds containing an Ssingle bondF bond have garnered intense interest in the
chemical and biological literature. In particular, sulfonyl fluorides (RSO 2 F) are commonly …

Photoredox catalytic radical fluorosulfonylation of olefins enabled by a bench-stable redox-active fluorosulfonyl radical precursor

P Wang, H Zhang, X Nie, T Xu, S Liao - Nature Communications, 2022 - nature.com
Sulfonyl fluorides have attracted considerable and growing research interests from various
disciplines, which raises a high demand for novel and effective methods to access this class …

Electrochemical Oxo‐Fluorosulfonylation of Alkynes under Air: Facile Access to β‐Keto Sulfonyl Fluorides

D Chen, X Nie, Q Feng, Y Zhang… - Angewandte Chemie …, 2021 - Wiley Online Library
Radical fluorosulfonylation is emerging as an appealing approach for the synthesis of
sulfonyl fluorides, which have widespread applications in many fields, in particular in the …

Divergent sulfur (VI) fluoride exchange linkage of sulfonimidoyl fluorides and alkynes

D Zeng, Y Ma, WP Deng, M Wang, X Jiang - Nature Synthesis, 2022 - nature.com
Sulfur (VI) fluoride exchange reactions have been applied to the linkage of a diverse range
of molecules. However, the connectivity of fluorosulfuryls with alkynes remains a formidable …

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Q Zheng, JL Woehl, S Kitamura… - Proceedings of the …, 2019 - National Acad Sciences
Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We
report here a SuFEx-enabled, agnostic approach for the discovery and optimization of …

Emerging building blocks for medicinal chemistry: recent synthetic advances

OO Grygorenko, DM Volochnyuk… - European Journal of …, 2021 - Wiley Online Library
Current medicinal chemistry relies heavily on the quality of building blocks, ie reagents used
to introduce chemical diversity into the target molecules. The last decade witnessed an …