Structural and functional diversity of neutrophil glycosylation in innate immunity and related disorders

J Ugonotti, S Chatterjee… - Molecular aspects of …, 2021 - Elsevier
The granulated neutrophils are abundant innate immune cells that utilize bioactive
glycoproteins packed in cytosolic granules to fight pathogenic infections, but the neutrophil …

Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics

MEH White, LR Sinn, DM Jones, J de Folter… - Nature Biomedical …, 2024 - nature.com
Protein glycosylation, a complex and heterogeneous post-translational modification that is
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …

Longitudinal proteomic profiling provides insights into host response and proteome dynamics in COVID‐19 progression

JS Lee, D Han, SY Kim, KH Hong, M Jang, MJ Kim… - …, 2021 - Wiley Online Library
In managing patients with coronavirus disease 2019 (COVID‐19), early identification of
those at high risk and real‐time monitoring of disease progression to severe COVID‐19 is a …

[HTML][HTML] Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities

HJCT Wessels, P Kulkarni, M van Dael… - Journal of Advanced …, 2024 - Elsevier
Introduction The human plasma glycoproteome holds enormous potential to identify
personalized biomarkers for diagnostics. Glycoproteomics has matured into a technology for …

Extensive heterogeneity of glycopeptides in plasma revealed by deep glycoproteomic analysis using size-exclusion chromatography

M Saraswat, K Garapati, DG Mun, A Pandey - Molecular Omics, 2021 - pubs.rsc.org
Several plasma glycoproteins are clinically useful as biomarkers in a variety of diseases.
Although thousands of proteins are present in plasma,> 95% of the plasma proteome by …

Transcriptome analysis of six tissues obtained post‐mortem from sepsis patients

F Pinheiro da Silva, ANA Gonçalves… - Journal of Cellular …, 2023 - Wiley Online Library
Septic shock is a life‐threatening clinical condition characterized by a robust immune
inflammatory response to disseminated infection. Little is known about its impact on the …

Serum N-Glycomics Stratifies Bacteremic Patients Infected with Different Pathogens

S Chatterjee, R Kawahara, HC Tjondro… - Journal of Clinical …, 2021 - mdpi.com
Bacteremia—ie, the presence of pathogens in the blood stream—is associated with long-
term morbidity and is a potential precursor condition to life-threatening sepsis. Timely …

Quantitative glycoproteomics of human milk and association with atopic disease

M Holm, M Saraswat, S Joenväärä, A Seppo… - PLoS …, 2022 - journals.plos.org
The prevalence of allergic diseases and asthma is increasing rapidly worldwide, with
environmental and lifestyle behaviors implicated as a reason. Epidemiological studies have …

[HTML][HTML] Altered microheterogeneity at several N‐glycosylation sites in OPSCC in constant protein expression conditions

A Dickinson, S Joenväärä, T Tohmola… - FASEB …, 2024 - ncbi.nlm.nih.gov
Protein glycosylation responds sensitively to disease states. It is implicated in every hallmark
of cancer and has recently started to be considered as a hallmark itself. Changes in N …

Differential peripheral blood glycoprotein profiles in symptomatic and asymptomatic COVID-19

C Pickering, B Zhou, G Xu, R Rice, P Ramachandran… - Viruses, 2022 - mdpi.com
Glycosylation is the most common form of post-translational modification of proteins, critically
affecting their structure and function. Using liquid chromatography and mass spectrometry …