Structural and functional diversity of neutrophil glycosylation in innate immunity and related disorders
J Ugonotti, S Chatterjee… - Molecular aspects of …, 2021 - Elsevier
The granulated neutrophils are abundant innate immune cells that utilize bioactive
glycoproteins packed in cytosolic granules to fight pathogenic infections, but the neutrophil …
glycoproteins packed in cytosolic granules to fight pathogenic infections, but the neutrophil …
Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
Protein glycosylation, a complex and heterogeneous post-translational modification that is
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …
Longitudinal proteomic profiling provides insights into host response and proteome dynamics in COVID‐19 progression
JS Lee, D Han, SY Kim, KH Hong, M Jang, MJ Kim… - …, 2021 - Wiley Online Library
In managing patients with coronavirus disease 2019 (COVID‐19), early identification of
those at high risk and real‐time monitoring of disease progression to severe COVID‐19 is a …
those at high risk and real‐time monitoring of disease progression to severe COVID‐19 is a …
[HTML][HTML] Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities
HJCT Wessels, P Kulkarni, M van Dael… - Journal of Advanced …, 2024 - Elsevier
Introduction The human plasma glycoproteome holds enormous potential to identify
personalized biomarkers for diagnostics. Glycoproteomics has matured into a technology for …
personalized biomarkers for diagnostics. Glycoproteomics has matured into a technology for …
Extensive heterogeneity of glycopeptides in plasma revealed by deep glycoproteomic analysis using size-exclusion chromatography
Several plasma glycoproteins are clinically useful as biomarkers in a variety of diseases.
Although thousands of proteins are present in plasma,> 95% of the plasma proteome by …
Although thousands of proteins are present in plasma,> 95% of the plasma proteome by …
Transcriptome analysis of six tissues obtained post‐mortem from sepsis patients
F Pinheiro da Silva, ANA Gonçalves… - Journal of Cellular …, 2023 - Wiley Online Library
Septic shock is a life‐threatening clinical condition characterized by a robust immune
inflammatory response to disseminated infection. Little is known about its impact on the …
inflammatory response to disseminated infection. Little is known about its impact on the …
Serum N-Glycomics Stratifies Bacteremic Patients Infected with Different Pathogens
S Chatterjee, R Kawahara, HC Tjondro… - Journal of Clinical …, 2021 - mdpi.com
Bacteremia—ie, the presence of pathogens in the blood stream—is associated with long-
term morbidity and is a potential precursor condition to life-threatening sepsis. Timely …
term morbidity and is a potential precursor condition to life-threatening sepsis. Timely …
Quantitative glycoproteomics of human milk and association with atopic disease
M Holm, M Saraswat, S Joenväärä, A Seppo… - PLoS …, 2022 - journals.plos.org
The prevalence of allergic diseases and asthma is increasing rapidly worldwide, with
environmental and lifestyle behaviors implicated as a reason. Epidemiological studies have …
environmental and lifestyle behaviors implicated as a reason. Epidemiological studies have …
[HTML][HTML] Altered microheterogeneity at several N‐glycosylation sites in OPSCC in constant protein expression conditions
A Dickinson, S Joenväärä, T Tohmola… - FASEB …, 2024 - ncbi.nlm.nih.gov
Protein glycosylation responds sensitively to disease states. It is implicated in every hallmark
of cancer and has recently started to be considered as a hallmark itself. Changes in N …
of cancer and has recently started to be considered as a hallmark itself. Changes in N …
Differential peripheral blood glycoprotein profiles in symptomatic and asymptomatic COVID-19
C Pickering, B Zhou, G Xu, R Rice, P Ramachandran… - Viruses, 2022 - mdpi.com
Glycosylation is the most common form of post-translational modification of proteins, critically
affecting their structure and function. Using liquid chromatography and mass spectrometry …
affecting their structure and function. Using liquid chromatography and mass spectrometry …