Biological membranes exhibit diversity in their shapes and complexity in chemical
compositions that are linked to many cellular functions. These two central features of …

Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation
system, but is also a major damage-associated molecular pattern (DAMP) that engages …

Our understanding of the role of membrane tension in the field of membrane biophysics is
rapidly evolving from a passive construct to an active player in a variety of cellular …

Many biological processes involve large-scale changes in membrane shape. Computer
simulations of these processes are challenging since they occur across a wide range of …

We report a method to generate de novo protein designs through a generative adversarial
neural network, MolShapeGAN, that can rapidly produce a large variety of nanoarchitected …

Spatiotemporal compartmentation of calcium dynamics is critical for neuronal function,
particularly in postsynaptic spines. This exquisite level of Ca2+ compartmentalization is …

Highlights•Drug binding is inherently multiscale as it occurs over a broad range of length
and time scales.•Multiscale simulation methods combine molecular descriptions to access …

Dendritic spines are small, bulbous compartments that function as postsynaptic sites and
undergo intense biochemical and biophysical activity. The role of the myriad signaling …

Morphology and function of the dorsolateral prefrontal cortex (dlPFC), and corresponding
working memory performance, are affected early in the aging process, but nearly half of …

Dendritic spines act as biochemical computational units and must adapt their responses
according to their activation history. Calcium influx acts as the first signaling step during …