Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor
prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve …

Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …

We performed the first proteogenomic characterization of hepatitis B virus (HBV)-related
hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 …

Recent molecular classifications of colorectal cancer (CRC) based on global gene
expression profiles have defined subtypes displaying resistance to therapy and poor …

The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …

The epithelial to mesenchymal transition (EMT) is a multistep biological process whereby
epithelial cells change in plasticity by transient de-differentiation into a mesenchymal …

Mortality owing to liver cancer has increased in the past 20 years, and the latest estimates
indicate that the global health burden of this disease will continue to grow. Most patients with …

Transforming growth factor-beta (TGF-β) signaling regulates a wide range of biological
processes. TGF-β plays an important role in tumorigenesis and contributes to the hallmarks …

The significant parallels between cell plasticity during embryonic development and
carcinoma progression have helped us understand the importance of the epithelial …

Epithelial–mesenchymal transition (EMT) is a key step in transdifferentiation process in solid
cancer development. Forthcoming evidence suggest that the stratified program transforms …