Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Every stage of cancer metastasis, immune surveillance evasion, and therapeutic resistance
is influenced by tumor microenvironment (TME). In light of this, nanomedicines design based …

Lineage-tracing methods have enabled characterization of clonal dynamics in complex
populations, but generally lack the ability to integrate genomic, epigenomic and …

Idiopathic pulmonary fibrosis (IPF) is characterized by lung scarring and has no effective
treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Oxaliplatin chemoresistance is a major challenge in the clinical treatment of colorectal
cancer (CRC), which is one of the most common malignancies worldwide. In this study, we …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

Background Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-
associated mortality. However, molecular mechanisms involved in ccRCC metastasis …

Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through
various mechanisms such as transcription, translation, protein modification and RNA-protein …

The protooncoprotein N-Myc, which is overexpressed in approximately 25% of
neuroblastomas as the consequence of MYCN gene amplification, has long been postulated …