Abstract In mammals, the Keap1-Nrf2-ARE pathway (henceforth,“the Nrf2 pathway”) and
autophagy are major intracellular defence systems that combat oxidative damage and …

Cortex fraxini is a widely used traditional Chinese medicine. Esculin is one of the main
active ingredients of Cortex fraxini and has attracted more and more attention from scholars …

Aging is one of the most serious factors for central nervous dysfunctions, which lead to
cognitive impairment. New highly effective drugs are required to slow the development of …

Calcium is a ubiquitous second messenger that is indispensable in regulating
neurotransmission and memory formation. A precise intracellular calcium level is achieved …

Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor related to stress
response and cellular homeostasis that plays a key role in maintaining the redox system …

By controlling several antioxidant and detoxifying genes at the transcriptional level,
including NAD (P) H quinone oxidoreductase 1 (NQO1), multidrug resistance-associated …

The zebrafish as an alternative animal model for developmental toxicity testing has been
extensively investigated, but its assay protocol was not harmonized yet. This study has …

Free radicals and other oxidants have enticed the interest of researchers in the fields of
biology and medicine, owing to their role in several pathophysiological conditions, including …

Flavobacterium columnare (F. columnare) is one of the deadliest fish pathogens causing
bacterial gill rot disease in various freshwater fish species globally. Tea polyphenols (TPs) …

Age-related eye diseases, including cataract, glaucoma, diabetic retinopathy (DR), and age-
related macular degeneration (AMD), are the leading causes of vision loss in the world …