The endoplasmic reticulum (ER) represents the entry point into the secretory pathway where
nascent proteins encounter a specialized environment for their folding and maturation …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

Many proteins must translocate through the protein-conducting Sec61 channel in the
eukaryotic endoplasmic reticulum membrane or the SecY channel in the prokaryotic plasma …

Many proteins are transported into the endoplasmic reticulum by the universally conserved
Sec61 channel. Post-translational transport requires two additional proteins, Sec62 and …

The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation
in eukaryotic cells, responsible for production of secretory proteins and most integral …

In eukaryotes, most secretory and membrane proteins are targeted by an N‐terminal signal
sequence to the endoplasmic reticulum, where the trimeric Sec61 complex serves as protein …

Methods that allow for the manipulation of genes or their products have been highly fruitful
for biomedical research. Here, we describe a method that allows the control of protein …

Background Tumor cells benefit from their ability to avoid apoptosis and invade other
tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these …

The ubiquitin fusion technique, developed in 1986, is still the method of choice for producing
a desired N‐terminal residue in a protein of interest in vivo. This technique is also used as a …

Because of similarity to their yeast orthologues, the two membrane proteins of the human
endoplasmic reticulum (ER) Sec62 and Sec63 are expected to play a role in protein …