Background Vanadium (V) is an element with a wide range of effects on the mammalian
organism. The ability of this metal to form organometallic compounds has contributed to the …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

The Mouse Metabolic Phenotyping Center (MMPC) Consortium was established to address
the need to characterize the growing number of mouse models of metabolic diseases …

Adipose tissue secretes proteins which may influence insulin sensitivity. Among them,
tumour necrosis factor (TNF)-alpha has been proposed as a link between obesity and …

Protein-tyrosine phosphatase 1B (PTP1B) is a major negative regulator of insulin and leptin
sensitivity. PTP1B overexpression in adipose tissue and skeletal muscle of humans and …

Insulin resistance is a major risk factor for developing type 2 diabetes caused by the inability
of insulin-target tissues to respond properly to insulin, and contributes to the morbidity of …

Despite increased use of the hyperinsulinemic-euglycemic clamp to study insulin action in
mice, the effects of experimental parameters on the results obtained have not been …

Zinc is a vital element in maintaining the normal structure and physiology of cells. The fact
that it has an important role in states of cardiovascular diseases has been studied and …

PTP1B, a non-transmembrane protein tyrosine phosphatase that has long been studied as a
negative regulator of insulin and leptin signaling, has received renewed attention as an …

It is now well established that the members of the PTP (protein tyrosine phosphatase)
superfamily play critical roles in fundamental biological processes. Although there has been …