Cerebral cavernous malformation: from mechanism to therapy

DA Snellings, CC Hong, AA Ren… - Circulation …, 2021 - Am Heart Assoc
Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

Cavernous angiomas: deconstructing a neurosurgical disease: JNSPG 75th Anniversary Invited Review Article

IA Awad, SP Polster - Journal of neurosurgery, 2019 - thejns.org
Cavernous angioma (CA) is also known as cavernoma, cavernous hemangioma, and
cerebral cavernous malformation (CCM)(National Library of Medicine Medical Subject …

Generation of vascularized brain organoids to study neurovascular interactions

XY Sun, XC Ju, Y Li, PM Zeng, J Wu, YY Zhou… - elife, 2022 - elifesciences.org
Brain organoids have been used to recapitulate the processes of brain development and
related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain …

Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

F Orsenigo, LL Conze, S Jauhiainen, M Corada… - Elife, 2020 - elifesciences.org
Cerebral cavernous malformation (CCM) is a rare neurovascular disease that is
characterized by enlarged and irregular blood vessels that often lead to cerebral …

Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation

MA Lopez-Ramirez, CC Lai, SI Soliman… - The Journal of …, 2021 - Am Soc Clin Investig
Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by
loss-of-function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …

Developmental venous anomalies are a genetic primer for cerebral cavernous malformations

DA Snellings, R Girard, R Lightle, A Srinath… - Nature cardiovascular …, 2022 - nature.com
Cerebral cavernous malformations (CCMs) are a neurovascular anomaly that may occur
sporadically or be inherited due to autosomal dominant mutations in KRIT1, CCM2 or …

Neuroinflammation plays a critical role in cerebral cavernous malformation disease

CC Lai, B Nelsen, E Frias-Anaya… - Circulation …, 2022 - Am Heart Assoc
Background: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused
by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …

Mild hypoxia accelerates cerebral cavernous malformation disease through cx3cr1-cx3cl1 signaling

E Frias-Anaya, H Gallego-Gutierrez… - … and Vascular Biology, 2024 - Am Heart Assoc
BACKGROUND: Heterogeneity in the severity of cerebral cavernous malformations (CCMs)
disease, including brain bleedings and thrombosis that cause neurological disabilities in …

Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation

MA Globisch, FC Onyeogaziri… - Blood, The Journal …, 2022 - ashpublications.org
Cerebral cavernous malformation (CCM) is a neurovascular disease that results in various
neurological symptoms. Thrombi have been reported in surgically resected CCM patient …

mPR-specific actions influence maintenance of the blood–brain barrier (BBB)

J Abou-Fadel, X Jiang, A Padarti, DG Goswami… - International Journal of …, 2022 - mdpi.com
Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated
intracranial microvascular sinusoids that result in increased susceptibility to hemorrhagic …